Letrozole Step-Up Protocol

moodie · Sep 6th, 2008, 18:57 PM

Has anyone done the Step-Up protocol with Letrozole? You would take one pill on CD3, two pills on CD4, three pills on CD5 and four pills on CD6. Another doctor is saying just to take one pill each day starting on CD3 and ending on CD7. Can anyone explain the purpose of the step-up doses?

pixielou · Sep 7th, 2008, 04:01 AM

Hi Moodie, I'm afraid I'm not familiar with this. What is it for?

moodie · Sep 7th, 2008, 10:03 AM

Letrozol is like Clomid but much safer and has less side effects. I took one 2.5mg pill for 5 days starting on CD3 a few cycles back but I over stimulated after taking two days of Puregon. Now the fertility clinic wants to try the step-up protocol as I decribed. I'm going to call to get more info but just wondering if anyone here has done this protocal.

loopylew · Sep 8th, 2008, 02:08 AM

sorry hun, can't help, ive not heard of that drug before x

pixielou · Sep 8th, 2008, 04:28 AM

Soz, don't know of this drug but hope that it goes well for you X

lonate · Sep 8th, 2008, 11:23 AM

I think I have taken letrozol. Isn't also called Femara? You can see from my siggy below that I have had 2 rounds of Femara 5g. The first time I took 2.5 mg 2 times daily on CD 5-9. The next cycle I took 2.5 mg 2 times daily on CD 3-9. I responded well to the drug. The 1st time I had 2 mature follies and the 2nd time I had 2 possibly 3 mature follies. Unfortunately I haven't gotten a

yet but I thought I would share my story.

Good Luck! I hope you get your

very soon!!
--Lesley

moodie · Sep 8th, 2008, 11:49 AM

Yes, the trade name is Famara. I've already had two doctors suggest Letrozole over Clomid.

seosage · Sep 8th, 2008, 11:58 AM

I used letrazole - but not the step up protocol. Agreed - it sounds an odd thing to do if the result last time was overstimulation. Sorry no help - are you going to get another chance to see the consultant before you do it?

moodie · Sep 8th, 2008, 12:24 PM

I just talked to the nurse and this time they would try the step-up protocol and not use the Puregon after the Letrozol. I guess it was the Puregon the over stimulated me. She said everyone reacts differently and they need to find what works for me.

seosage · Sep 8th, 2008, 12:39 PM

Ah - well that makes more sense - I got overstimulated on the lowest dose of Puregon too - sounds like your clinic liked the same drugs that mine did.

Sep 6th, 2008, 18:57 PM	#1
moodie Trying to conceive (TTC) Active BnB Member Join Date: Aug 2008 Posts: 22	Letrozole Step-Up Protocol Has anyone done the Step-Up protocol with Letrozole? You would take one pill on CD3, two pills on CD4, three pills on CD5 and four pills on CD6. Another doctor is saying just to take one pill each day starting on CD3 and ending on CD7. Can anyone explain the purpose of the step-up doses?

Status: Offline

Sep 7th, 2008, 04:01 AM	#2
pixielou Trying to conceive (TTC) Active BnB Member Join Date: Nov 2007 Location: London Posts: 746	Hi Moodie, I'm afraid I'm not familiar with this. What is it for?

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Sep 7th, 2008, 10:03 AM	#3
moodie Trying to conceive (TTC) Active BnB Member Join Date: Aug 2008 Posts: 22	Letrozol is like Clomid but much safer and has less side effects. I took one 2.5mg pill for 5 days starting on CD3 a few cycles back but I over stimulated after taking two days of Puregon. Now the fertility clinic wants to try the step-up protocol as I decribed. I'm going to call to get more info but just wondering if anyone here has done this protocal.

Status: Offline

Sep 8th, 2008, 02:08 AM	#4
loopylew Mum (Mom) Chat Happy BnB Member Join Date: Nov 2007 Location: Yorkshire, UK Posts: 2,344	sorry hun, can't help, ive not heard of that drug before x

Status: Offline

Sep 8th, 2008, 04:28 AM	#5
pixielou Trying to conceive (TTC) Active BnB Member Join Date: Nov 2007 Location: London Posts: 746	Soz, don't know of this drug but hope that it goes well for you X

Status: Offline

Sep 8th, 2008, 11:23 AM	#6
lonate Trying to conceive (TTC) Active BnB Member Join Date: Jun 2008 Location: Indiana Posts: 160	I think I have taken letrozol. Isn't also called Femara? You can see from my siggy below that I have had 2 rounds of Femara 5g. The first time I took 2.5 mg 2 times daily on CD 5-9. The next cycle I took 2.5 mg 2 times daily on CD 3-9. I responded well to the drug. The 1st time I had 2 mature follies and the 2nd time I had 2 possibly 3 mature follies. Unfortunately I haven't gotten a yet but I thought I would share my story. Good Luck! I hope you get your very soon!! --Lesley

Status: Offline

Sep 8th, 2008, 11:49 AM	#7
moodie Trying to conceive (TTC) Active BnB Member Join Date: Aug 2008 Posts: 22	Yes, the trade name is Famara. I've already had two doctors suggest Letrozole over Clomid.

Status: Offline

Sep 8th, 2008, 11:58 AM	#8
seosage Mum (Mom) Active BnB Member Join Date: May 2008 Location: Hampshire, UK Posts: 56	I used letrazole - but not the step up protocol. Agreed - it sounds an odd thing to do if the result last time was overstimulation. Sorry no help - are you going to get another chance to see the consultant before you do it?

Status: Offline

Sep 8th, 2008, 12:24 PM	#9
moodie Trying to conceive (TTC) Active BnB Member Join Date: Aug 2008 Posts: 22	I just talked to the nurse and this time they would try the step-up protocol and not use the Puregon after the Letrozol. I guess it was the Puregon the over stimulated me. She said everyone reacts differently and they need to find what works for me.

Status: Offline

Sep 8th, 2008, 12:39 PM	#10
seosage Mum (Mom) Active BnB Member Join Date: May 2008 Location: Hampshire, UK Posts: 56	Ah - well that makes more sense - I got overstimulated on the lowest dose of Puregon too - sounds like your clinic liked the same drugs that mine did.

Status: Offline

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