downregulation question

Trying4ever · Dec 16th, 2009, 15:00 PM

Ladies who have been through IVF/ICSI or who knows about the procedure.....before starting IVF you have to 'downregulate ' on cd21 or so....did you ever have any doubts that you may be pregnant naturally that month?

and if so, is it dangerous to downregulate when you are pregnant? Like probably 7 days!

Also what is the procedure? You downregulate for 7 days then start gonal f injections until enough follicles? I cant get a clear picture on what happens....so many stories flying about using differnt things

MissMonty · Dec 16th, 2009, 16:06 PM

Hello, I'm starting down regging next week on cycle day 21, fertility nurse advised AF should arrive as usual 7 days later but if not to do pregnancy test, she didn't advise us not to try so I guess it is ok. TBH we have had a break this month as I was worried like you that it could cause a problem but also because I've been feeling really exhausted by it all.

Before you start the procedure the fertility clinic will send you a protocol of what will happen when, we're still waiting for ours so I can't really help any further.

We recieved all the drugs though today - I can't believe the size of the box it all came in and all the neddles etc, tbh it's kind of freaked me out. We've got injection training the day before I start down regging so I guess I'll find out more then.

Are you starting treatment soon? x

Dilek · Dec 16th, 2009, 17:54 PM

Im sure they have checks for this, they must do a scan.

With the stimulation they give you 2 scan appointment to check follicle number and most important the follicle size. Once there at 18mm you are ready to do trigger shot and have egg collection done.

SO depending on how quick your follicles grow is how long you will stimulate your ovaries.

Dilek · Dec 16th, 2009, 17:59 PM

1. Down regulation - can take 3 weeks. They check your womb lining and it should be around 10mm (thickness)

2. Stimulate, can vary in drugs depending on circumstances, is usually around 10-14 days. You should have a check on day 6 of injection and one around day 10. You will then be given a day you will have egg collection and when to do your trigger shot. This shot bursts eggs into the follciles. After 36-48 hours you will have egg collection. Egg transfer can be on day 2 to day 5.

3. Dreaded 2 week wait after egg collection begins, You will be on presseries which you have to put inside you. this will help to support pregnancy.

4. You will be asked to do a test at home or in the clinic and you might be lucky to have a blood test to confirm.

Thats it hun, easy as that! hope that helps. It is daunting at 1st.

3.

Trying4ever · Dec 17th, 2009, 17:21 PM

Thanks Dilek that has really helped....not as bad as I thought.....but just lots of days off from work I suppose! What am i going to say to them? I have decided I def don't want to tell anyone from work cos the pressure is awful.

MissMonty..your starting downreg next week? What day? We have an information session next week and may just start IVF straight away...all our tests are done...otherwsie we have appointment in Jan to start IVF next month instead. I was just worried about starting too early...but I suppose if downreg is not harmful and you can still do a preg test/AF comes normally before the stimulation drugs then I need not worry.....but I will ask in the information session.

HevTT · Dec 17th, 2009, 17:43 PM

My position is slightly different but.....

I was given a down-regulating injection 4 weeks ago and they intend to start egg stimulation in March. The reason for this is that I had endo blasted, cyst removed and an ovary kinda but not completely removed from my bowel. They have started the down-regulation but have told me to use protection meantime as the drugs can have harmful effects on an unborn baby.

Hev x

Trying4ever · Dec 17th, 2009, 17:51 PM

ooooooooooh......is it? can you have ivf without the downregulation then? I responded well to 100mg clomid and even the stimulation injections on its own when i was having iui....think it may be male factor infertility ..........

HevTT · Dec 17th, 2009, 18:23 PM

I don't think you can have IVF without the down-regulation (although to be honest, I have no idea!). I am going for a blood test in the morning (as the fertility clinic are doing a study on endo and looking for 'markers' in women who have it - so they can come up with a test like the diabetic one, avoiding the need for surgery to diagnose endo) but the nurse I am seeing in the morning is one of the fertility nurses and is used to me asking a load of questions

....I'll ask her

....oh, and I'll ask her about the normal down-regulation drugs and whether you should be using protection meantime.

Hev x

MissMonty · Dec 18th, 2009, 14:00 PM

Quote:

Originally Posted by Trying4ever

Thanks Dilek that has really helped....not as bad as I thought.....but just lots of days off from work I suppose! What am i going to say to them? I have decided I def don't want to tell anyone from work cos the pressure is awful.

MissMonty..your starting downreg next week? What day? We have an information session next week and may just start IVF straight away...all our tests are done...otherwsie we have appointment in Jan to start IVF next month instead. I was just worried about starting too early...but I suppose if downreg is not harmful and you can still do a preg test/AF comes normally before the stimulation drugs then I need not worry.....but I will ask in the information session.

Hi Trying4ever, I'm starting downreg on Wednesday, got injection training on Tuesday. I was told to start down regging on cycle day 21. Yeah defo find out at your information session just to be safe x

Beckic · Dec 18th, 2009, 14:07 PM

Hi Hun - was told with my two cycles not to try at all or to use protection before the DR - I really think to be on the safeside its best not to.

There is another protocol called antagonist - I literally only found out about this yesterday at my review - that you dont have to DR for - they just give you stimms to supplement your natural hormones. Have no idea whether its better than the long portocol that I was on before - but willing to try anything at this stage.

Good luck hun.
BX xx

Dec 16th, 2009, 15:00 PM	#1
Trying4ever Trying to conceive (TTC) Active BnB Member Join Date: Oct 2008 Location: LONDON Posts: 481	downregulation question Ladies who have been through IVF/ICSI or who knows about the procedure.....before starting IVF you have to 'downregulate ' on cd21 or so....did you ever have any doubts that you may be pregnant naturally that month? and if so, is it dangerous to downregulate when you are pregnant? Like probably 7 days! Also what is the procedure? You downregulate for 7 days then start gonal f injections until enough follicles? I cant get a clear picture on what happens....so many stories flying about using differnt things

Status: Offline

Dec 16th, 2009, 16:06 PM	#2
MissMonty Pregnant (Expecting) Chat Happy BnB Member Join Date: Jan 2008 Location: UK Posts: 1,193	Hello, I'm starting down regging next week on cycle day 21, fertility nurse advised AF should arrive as usual 7 days later but if not to do pregnancy test, she didn't advise us not to try so I guess it is ok. TBH we have had a break this month as I was worried like you that it could cause a problem but also because I've been feeling really exhausted by it all. Before you start the procedure the fertility clinic will send you a protocol of what will happen when, we're still waiting for ours so I can't really help any further. We recieved all the drugs though today - I can't believe the size of the box it all came in and all the neddles etc, tbh it's kind of freaked me out. We've got injection training the day before I start down regging so I guess I'll find out more then. Are you starting treatment soon? x

Status: Offline

Dec 16th, 2009, 17:54 PM	#3
Dilek Mum (Mom) Chat Happy BnB Member Join Date: Nov 2008 Location: London Posts: 2,228	Im sure they have checks for this, they must do a scan. With the stimulation they give you 2 scan appointment to check follicle number and most important the follicle size. Once there at 18mm you are ready to do trigger shot and have egg collection done. SO depending on how quick your follicles grow is how long you will stimulate your ovaries.

Status: Offline

Dec 16th, 2009, 17:59 PM	#4
Dilek Mum (Mom) Chat Happy BnB Member Join Date: Nov 2008 Location: London Posts: 2,228	1. Down regulation - can take 3 weeks. They check your womb lining and it should be around 10mm (thickness) 2. Stimulate, can vary in drugs depending on circumstances, is usually around 10-14 days. You should have a check on day 6 of injection and one around day 10. You will then be given a day you will have egg collection and when to do your trigger shot. This shot bursts eggs into the follciles. After 36-48 hours you will have egg collection. Egg transfer can be on day 2 to day 5. 3. Dreaded 2 week wait after egg collection begins, You will be on presseries which you have to put inside you. this will help to support pregnancy. 4. You will be asked to do a test at home or in the clinic and you might be lucky to have a blood test to confirm. Thats it hun, easy as that! hope that helps. It is daunting at 1st. 3.

Status: Offline

Dec 17th, 2009, 17:21 PM	#5
Trying4ever Trying to conceive (TTC) Active BnB Member Join Date: Oct 2008 Location: LONDON Posts: 481	Thanks Dilek that has really helped....not as bad as I thought.....but just lots of days off from work I suppose! What am i going to say to them? I have decided I def don't want to tell anyone from work cos the pressure is awful. MissMonty..your starting downreg next week? What day? We have an information session next week and may just start IVF straight away...all our tests are done...otherwsie we have appointment in Jan to start IVF next month instead. I was just worried about starting too early...but I suppose if downreg is not harmful and you can still do a preg test/AF comes normally before the stimulation drugs then I need not worry.....but I will ask in the information session.

Status: Offline

Dec 17th, 2009, 17:43 PM	#6
HevTT Trying to conceive (TTC) Active BnB Member Join Date: Nov 2008 Posts: 25	My position is slightly different but..... I was given a down-regulating injection 4 weeks ago and they intend to start egg stimulation in March. The reason for this is that I had endo blasted, cyst removed and an ovary kinda but not completely removed from my bowel. They have started the down-regulation but have told me to use protection meantime as the drugs can have harmful effects on an unborn baby. Hev x

Status: Offline

Dec 17th, 2009, 17:51 PM	#7
Trying4ever Trying to conceive (TTC) Active BnB Member Join Date: Oct 2008 Location: LONDON Posts: 481	ooooooooooh......is it? can you have ivf without the downregulation then? I responded well to 100mg clomid and even the stimulation injections on its own when i was having iui....think it may be male factor infertility ..........

Status: Offline

Dec 17th, 2009, 18:23 PM	#8
HevTT Trying to conceive (TTC) Active BnB Member Join Date: Nov 2008 Posts: 25	I don't think you can have IVF without the down-regulation (although to be honest, I have no idea!). I am going for a blood test in the morning (as the fertility clinic are doing a study on endo and looking for 'markers' in women who have it - so they can come up with a test like the diabetic one, avoiding the need for surgery to diagnose endo) but the nurse I am seeing in the morning is one of the fertility nurses and is used to me asking a load of questions ....I'll ask her ....oh, and I'll ask her about the normal down-regulation drugs and whether you should be using protection meantime. Hev x

Status: Offline

Dec 18th, 2009, 14:07 PM	#10
Beckic Trying to conceive (TTC) Chat Happy BnB Member Join Date: Feb 2008 Location: Watford Posts: 1,434	Hi Hun - was told with my two cycles not to try at all or to use protection before the DR - I really think to be on the safeside its best not to. There is another protocol called antagonist - I literally only found out about this yesterday at my review - that you dont have to DR for - they just give you stimms to supplement your natural hormones. Have no idea whether its better than the long portocol that I was on before - but willing to try anything at this stage. Good luck hun. BX xx

Status: Offline

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