Trimethoprim 100mg ???

mummy0704 · Nov 28th, 2009, 14:59 PM

Hi i've been to hospital today and i have a chest, ear and sinus infection, the doc gave me 28 trimethoprim antibiotics, but when i went to chemist they made me sign a form declaring i knew they can cause abnormalities in unborn babies, i havent taken any and dont know what to do, anyone had any ? or know anything about them good or bad just need to know, thanks x x

purpledaisy2 · Nov 28th, 2009, 15:09 PM

I had them at about 15 weeks for a kidney infection, I wasnt made to sign anything and didnt have problems taking them?

Maybe give your docs a call in the morning if you want some re-assurance x

plumplump · Nov 28th, 2009, 15:11 PM

Hi Hunny I just checked the BNF and it states that cautions should be taken but only in first trimester x

lili24 · Nov 28th, 2009, 15:12 PM

I always get water infections and this is the antibiotic I am normally precribed. When I became pregnant though the Dr changed it and said it is not recommended during pregnancy. I believe it stops folic acid from being absorbed so can therefore cause abnormalities that way. Since you are way past that stage it may be safe for you to take. Could you give nhs direct a call and check? Xx

mummy0704 · Nov 28th, 2009, 15:14 PM

thankyou everyone sounds like there ok now i'm further along, thankyou for helping x x

lili24 · Nov 28th, 2009, 15:15 PM

Hope you feel better soon

xx

JessiHD · Nov 28th, 2009, 15:22 PM

I think you might need to take a folic acid supplement alongside it:

http://www.inhousepharmacy.co.uk/inf...formation.html

Use During Pregnancy and Lactation

The safety of trimethoprim in human pregnancy has not been established.

At doses greatly in excess of the recommended human therapeutic dose trimethoprim has been reported to be teratogenic in rats with effects typical of a folate antagonist and preventable by administration of dietary folate. No significant medicine-related malformations have been demonstrated in rabbits but at doses approximately ten times in excess of the human therapeutic dose an increase in foetal deaths was noted.

Despite its excretion in breast milk the administration of Triprim to lactating women represents a negligible risk to the suckling infant.

kaleidoscope · Nov 28th, 2009, 15:24 PM

I would personally call your gp tomorrow..its not suitable for use in the first trimester which you are past, however its safety during pregnancy hasnt been established...Amoxycillin is the anti biotic of choice in pregnancy but it may be that your infection is severe and would not respond to the usual dosage of amoxycillin..its probably one of those benefits outweigh the risks scenario but double check with your gp

mummy0704 · Nov 28th, 2009, 15:35 PM

hi i'm alergic to all penicilli, erithramicin, amoxacillin, kefalexin. (sorry bad spelling) so thats why they gave it me. i've had this infection over a week now so think i'll just put up with it till monday morning and speak to my own doc, think its going to be the best way dont u ???

kaleidoscope · Nov 28th, 2009, 16:00 PM

ah..this is why they have prescribed trimthroprim....the main problem seems to be that it is a folic acid antagonist..unfortunately tetracyclines are not suitible in pregnancy so you couldnt be prescribed doxycycline which usually works well against these type of infections

just out of curiousity you say you are allergic to penicillin..cephalexin is a cephalosporin not a penicillin..although it does behave in a similiar way to penicillin

Nov 28th, 2009, 14:59 PM	#1
mummy0704 Mum (Mom) Chat Happy BnB Member Join Date: Jun 2009 Location: huddersfield Posts: 2,130	Trimethoprim 100mg ??? Hi i've been to hospital today and i have a chest, ear and sinus infection, the doc gave me 28 trimethoprim antibiotics, but when i went to chemist they made me sign a form declaring i knew they can cause abnormalities in unborn babies, i havent taken any and dont know what to do, anyone had any ? or know anything about them good or bad just need to know, thanks x x

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Nov 28th, 2009, 15:09 PM	#2
purpledaisy2 Mum (Mom) BnB Addict Join Date: Dec 2008 Location: Up North, UK Posts: 3,654	I had them at about 15 weeks for a kidney infection, I wasnt made to sign anything and didnt have problems taking them? Maybe give your docs a call in the morning if you want some re-assurance x

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Nov 28th, 2009, 15:11 PM	#3
plumplump Mum (Mom) Active BnB Member Join Date: Feb 2009 Location: Fife, Scotland Posts: 292	Hi Hunny I just checked the BNF and it states that cautions should be taken but only in first trimester x

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Nov 28th, 2009, 15:12 PM	#4
lili24 Mum (Mom) BnB Addict Join Date: Dec 2008 Posts: 3,365	I always get water infections and this is the antibiotic I am normally precribed. When I became pregnant though the Dr changed it and said it is not recommended during pregnancy. I believe it stops folic acid from being absorbed so can therefore cause abnormalities that way. Since you are way past that stage it may be safe for you to take. Could you give nhs direct a call and check? Xx

Status: Offline

Nov 28th, 2009, 15:14 PM	#5
mummy0704 Mum (Mom) Chat Happy BnB Member Join Date: Jun 2009 Location: huddersfield Posts: 2,130	thankyou everyone sounds like there ok now i'm further along, thankyou for helping x x

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Nov 28th, 2009, 15:15 PM	#6
lili24 Mum (Mom) BnB Addict Join Date: Dec 2008 Posts: 3,365	Hope you feel better soon xx

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Nov 28th, 2009, 15:22 PM	#7
JessiHD Mum (Mom) Chat Happy BnB Member Join Date: Aug 2009 Location: Birmingham, West Midlands Posts: 1,201	I think you might need to take a folic acid supplement alongside it: http://www.inhousepharmacy.co.uk/inf...formation.html Use During Pregnancy and Lactation The safety of trimethoprim in human pregnancy has not been established. At doses greatly in excess of the recommended human therapeutic dose trimethoprim has been reported to be teratogenic in rats with effects typical of a folate antagonist and preventable by administration of dietary folate. No significant medicine-related malformations have been demonstrated in rabbits but at doses approximately ten times in excess of the human therapeutic dose an increase in foetal deaths was noted. Despite its excretion in breast milk the administration of Triprim to lactating women represents a negligible risk to the suckling infant.

Status: Offline

Nov 28th, 2009, 15:24 PM	#8
kaleidoscope Pregnant (Expecting) Active BnB Member Join Date: Nov 2009 Location: Chester Posts: 413	I would personally call your gp tomorrow..its not suitable for use in the first trimester which you are past, however its safety during pregnancy hasnt been established...Amoxycillin is the anti biotic of choice in pregnancy but it may be that your infection is severe and would not respond to the usual dosage of amoxycillin..its probably one of those benefits outweigh the risks scenario but double check with your gp

Status: Offline

Nov 28th, 2009, 15:35 PM	#9
mummy0704 Mum (Mom) Chat Happy BnB Member Join Date: Jun 2009 Location: huddersfield Posts: 2,130	hi i'm alergic to all penicilli, erithramicin, amoxacillin, kefalexin. (sorry bad spelling) so thats why they gave it me. i've had this infection over a week now so think i'll just put up with it till monday morning and speak to my own doc, think its going to be the best way dont u ???

Status: Offline

Nov 28th, 2009, 16:00 PM	#10
kaleidoscope Pregnant (Expecting) Active BnB Member Join Date: Nov 2009 Location: Chester Posts: 413	ah..this is why they have prescribed trimthroprim....the main problem seems to be that it is a folic acid antagonist..unfortunately tetracyclines are not suitible in pregnancy so you couldnt be prescribed doxycycline which usually works well against these type of infections just out of curiousity you say you are allergic to penicillin..cephalexin is a cephalosporin not a penicillin..although it does behave in a similiar way to penicillin

Status: Offline

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